High-Protein Pizza Breakfast Casserole

Featured in: Everyday Cozy Meals

This hearty breakfast dish combines a simple two-ingredient Greek yogurt dough base with a classic pizza flavor profile. The crust comes together quickly with just flour and yogurt, creating a sturdy foundation for the egg and cheese topping. Turkey pepperoni adds savory depth while keeping things lighter than traditional versions.

Ideal for meal prep Sundays, this casserole slices beautifully and reheats well throughout the week. The high protein content from eggs, Greek yogurt, and cheese makes it especially satisfying for busy mornings.

Updated on Mon, 09 Feb 2026 12:02:00 GMT
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni right out of the oven. Save to Pinterest
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese and turkey pepperoni right out of the oven. | recipesforevers.com

My Sunday meal prep routine completely transformed the moment I stopped overthinking breakfast and started building it like pizza. There's something deeply satisfying about layering a Greek yogurt dough, then pouring eggs over it, then finishing with cheese and pepperoni—it feels indulgent but reads as smart nutrition. This casserole emerged from a lazy morning when I had leftover turkey pepperoni, Greek yogurt I needed to use, and absolutely no patience for cooking six separate breakfasts during the week. What started as improvisation became my go-to recipe whenever I need to feed people without the circus of standing at a stove.

I brought this to a chaotic Saturday morning potluck where everyone arrived hungry and skeptical because, let's be honest, casseroles can be beige and forgettable. Someone asked if it was actually pizza disguised as a responsible breakfast, and the whole table nodded while eating thirds. That's when I realized this wasn't just convenient—it was genuinely crave-worthy, which is the difference between a recipe that works and one that becomes habit.

Ingredients

  • All-purpose flour: Just 1½ cups creates a light, tender base that's thinner than pizza dough but sturdy enough to hold the egg custard without sogginess; don't skip the baking powder or your dough stays dense.
  • Plain Greek yogurt: Nonfat or 2% works equally well and replaces the oil or butter you'd normally add to dough, keeping your protein count high without heaviness; it makes the base naturally tender.
  • Eggs: Eight large ones are the binding backbone of your casserole, and they should be room temperature so they mix smoothly and set evenly without overcooked edges.
  • Milk: Low-fat keeps the protein focus sharp while adding just enough liquid so the eggs set to custardy rather than rubbery; whole milk works if that's what you have.
  • Shredded cheeses: Part-skim mozzarella melts beautifully and provides that familiar pizza character, while reduced-fat cheddar adds sharp depth—mixing two varieties beats using just one.
  • Turkey pepperoni: Its saltiness and subtle smoke are essential; regular pepperoni works if that's your preference, though it'll shift the fat content slightly.
  • Oregano and garlic powder: These aren't optional if you want the pizza illusion to feel complete; they're the flavor whisper that makes people ask what's different about this breakfast.

Instructions

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Heat the oven and prep your canvas:
Preheat to 375°F while you lightly grease your 9x13-inch pan—use a pastry brush or crumpled paper towel with a touch of oil so the dough doesn't stick but stays thin and crispy on the bottom.
Mix the dough without overthinking it:
Whisk flour, baking powder, and salt together, then add Greek yogurt and stir just until a shaggy dough forms; knead for maybe thirty seconds until it's smooth and unified. Don't work it hard or your base will be tough instead of tender.
Press and flatten your foundation:
Transfer the dough to your pan and press it evenly across the bottom and slightly up the sides, using damp fingers so it doesn't stick to you. Aim for about quarter-inch thickness so it bakes through without burning on the edges.
Whisk the egg custard:
Crack all eight eggs into a large bowl, add milk, oregano, garlic powder, and black pepper, then whisk until the mixture is pale yellow and completely smooth. This is where your seasoning distributes evenly, so don't skip the whisking.
Build the layers:
Pour the egg mixture gently over your dough base, letting it find the edges and settle evenly. Sprinkle both cheeses across the surface, then scatter turkey pepperoni slices over everything so each slice gets some protein and cheese to grip.
Bake until golden and set:
Slide into the oven for 20 to 25 minutes—you're looking for the eggs to be just set (a slight jiggle in the center is fine) and the cheese to have turned golden and bubbly at the edges. Every oven runs hot or cool, so check at 20 minutes first.
Rest and garnish:
Pull it out and let it sit for five minutes so the casserole firms up and becomes easier to slice cleanly. A handful of fresh parsley scattered across the top adds color and brightness, though it's entirely optional.
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A slice of High-Protein Pizza Breakfast Casserole is lifted to reveal fluffy eggs and a Greek yogurt dough crust. Save to Pinterest
A slice of High-Protein Pizza Breakfast Casserole is lifted to reveal fluffy eggs and a Greek yogurt dough crust. | recipesforevers.com

My roommate used to say breakfast was just fuel, until she tasted this warm from the oven and asked for the recipe before she'd even finished her first slice. Watching someone's whole perspective shift over something as simple as pizza flavor at 8 a.m. reminded me that cooking isn't about complexity—it's about making people feel seen by the effort you've put in.

Variations That Actually Work

The beauty of this casserole is how willing it is to adapt without losing its identity. Bell peppers, mushrooms, or fresh spinach add nutrition and texture without overwhelming the pizza concept—just chop them small and scatter them over the dough before pouring the eggs so they have time to soften. Chicken sausage or vegetarian pepperoni swap in seamlessly if you're feeding people with different preferences, and honestly, each version tastes just as crave-worthy as the original.

Timing and Meal Prep Reality

This casserole actually improves slightly when made a day ahead and reheated gently in a low oven—the flavors meld overnight and it slices cleaner when cold. Pack individual squares in containers, refrigerate for up to five days, and reheat in a 325°F oven for about eight minutes, or microwave individual portions for ninety seconds if mornings are as rushed as mine usually are.

Serving and Pairing Ideas

This stands alone as a complete meal, but it sings when paired with simple sides that don't compete with the pizza flavor you've built in. A small green salad dressed with lemon and olive oil provides freshness and lightness, while marinara sauce for dipping (as suggested in the original notes) taps into pure pizza nostalgia and works beautifully for people who want that familiar ritual.

  • Warm it slightly before serving if you've made it ahead—cold casserole tastes dense, but just-warm feels indulgent and custardy.
  • Slice with a sharp knife dipped in hot water and wiped clean between cuts so the pieces stay defined instead of dragging into each other.
  • Double the recipe in two pans if you're feeding a crowd, because one casserole rarely stays around long enough to regret making too much.
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Served High-Protein Pizza Breakfast Casserole with a side of marinara sauce for dipping, perfect for a healthy morning meal. Save to Pinterest
Served High-Protein Pizza Breakfast Casserole with a side of marinara sauce for dipping, perfect for a healthy morning meal. | recipesforevers.com

There's quiet magic in a recipe that looks fancy enough for weekend entertaining but tastes like something you'd genuinely want for a Tuesday morning. This casserole is that recipe.

Recipe FAQs

Can I make this ahead of time?

Yes, this casserole reheats beautifully. Store sliced portions in the refrigerator for up to 5 days and warm in the microwave for 1-2 minutes before serving.

What type of Greek yogurt works best?

Plain Greek yogurt, either nonfat or 2%, works perfectly. The thicker texture of Greek yogurt creates a better dough consistency compared to regular yogurt.

Can I freeze this casserole?

Absolutely. Wrap individual slices or the entire casserole tightly and freeze for up to 3 months. Thaw overnight in the refrigerator before reheating.

What other toppings can I add?

Diced bell peppers, mushrooms, spinach, onions, or black olives work wonderfully. You can also substitute turkey pepperoni with cooked sausage or bacon.

Is the dough difficult to work with?

Not at all. The Greek yogurt dough is very forgiving and easy to press into the pan. It's more like pressing a crust into a dish than traditional kneading.

Can I use a different size pan?

A 9x13-inch pan works best for the proper thickness. Using a smaller pan will make the crust thicker and require longer baking time.

High-Protein Pizza Breakfast Casserole

Savory breakfast bake with Greek yogurt crust, eggs, pepperoni and cheese

Prep Duration
20 minutes
Time to Cook
25 minutes
Complete Duration
45 minutes

Recipe Type Everyday Cozy Meals

Complexity Easy

Cuisine American

Makes 6 Portions

Dietary Info None specified

What You Need

Greek Yogurt Dough

01 1½ cups all-purpose flour
02 2 teaspoons baking powder
03 ½ teaspoon salt
04 1 cup plain Greek yogurt

Toppings

01 8 large eggs
02 ½ cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 ½ cup shredded reduced-fat cheddar cheese
05 ½ cup turkey pepperoni slices
06 ½ teaspoon dried oregano
07 ½ teaspoon garlic powder
08 ¼ teaspoon black pepper
09 2 tablespoons chopped fresh parsley

Directions

Step 01

Prepare Baking Pan: Preheat oven to 375°F. Lightly grease a 9x13-inch sheet pan or casserole dish.

Step 02

Mix Dough Base: In a medium bowl, whisk together flour, baking powder, and salt. Add Greek yogurt and mix with a spoon until a shaggy dough forms. Knead briefly until smooth.

Step 03

Form Dough Layer: Press the dough evenly into the prepared pan, forming a thin, uniform base.

Step 04

Prepare Egg Mixture: In a large bowl, whisk together eggs, milk, oregano, garlic powder, and black pepper until well combined.

Step 05

Assemble Casserole: Pour the egg mixture evenly over the dough base. Sprinkle mozzarella and cheddar cheese over the eggs. Top with turkey pepperoni slices.

Step 06

Bake: Bake for 20 to 25 minutes, or until the eggs are set and the cheese is golden and bubbly.

Step 07

Finish and Serve: Let cool for 5 minutes, then garnish with fresh parsley if desired. Slice and serve warm.

Essential Tools

  • 9x13-inch sheet pan or casserole dish
  • Mixing bowls
  • Whisk
  • Measuring cups and spoons
  • Knife and cutting board

Allergy Details

Be sure to check every item for allergens. If uncertain, talk with a healthcare provider.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy
  • Check turkey pepperoni and cheese labels for potential cross-contamination

Nutrition per serving

Nutrition details are for your reference only. Always speak with a professional for medical concerns.
  • Caloric Content: 260
  • Total Fat: 10 grams
  • Carbohydrates: 19 grams
  • Proteins: 22 grams